SP600125 is a novel, potent, and selective ATP-competitive inhibitor of JNK-1, JNK-2, and JNK-3. It induces dose-dependent inhibition of c-Jun phosphorylation and reduces the expression of inflammatory genes including IL-2, COX-2, TNF-α, and IFN-γ. It also blocks the activation and differentiation of primary human CD4 cell cultures and exerts inhibitory effects on tumor cell proliferation, endothelial cell migration, and tumor growth.
- Selective JNK-1, -2, and -3 inhibitor
- Inhibits c-Jun phosphorylation and inflammatory gene expression
- Suppresses tumor cell proliferation and endothelial cell migration
- Blocks tumor and endothelial cells in the G2 phase of the cell cycle
- High purity >99%
- Molecular weight: 220.23 g/mol
- Supplied as lyophilized powder